Study finds vitamin D supplementation does not reduce bone fracture risk

A new study found that vitamin D3 Supplementation (2000 IU/day) does not reduce total, non-vertebral or hip fractures, and no effect was observed on major osteoporotic fractures, wrist fractures, or pelvic fractures.

Vitamin D supplements are widely prescribed and used to benefit bone health. However, definitive data on whether these supplements actually reduce bone fractures in the general population have been inconsistent.

To improve scientific understanding of this topic, a team of scientists from Brigham and Women’s Hospital conducted a secondary study of VITamin D and Omega-3 TriaL (VITAL), a clinical trial of more than 25,000 adults, also led by Brigham investigators. A total of 1,991 accident fractures were confirmed in 1,551 participants over a median follow-up of 5.3 years.

“Overall, the results of this large clinical trial do not support the use of vitamin D supplementation to reduce fractures in generally healthy American men and women.” – Meryl LeBeouf, MD

According to the results, take a vitamin D supplement3 (2000 IU/day) did not reduce total, non-vertebral, or hip fractures compared to placebo. Additionally, there were no effects of supplemental vitamin D3 On major osteoporotic fractures, wrist fractures, or pelvic fractures. In the analysis, effects were not adjusted for baseline age, gender, race, body mass index, baseline blood levels of vitamin D, and personal use of supplemental calcium and/or vitamin D.

“Overall, the results of this large clinical trial do not support the use of vitamin D supplementation to reduce fractures in generally healthy American men and women,” said lead author Meryl LeBeouf, MD, chief of calcium and bone in the division of endocrinology. in Brigham.

These findings do not apply to adults with vitamin D deficiency, low bone mass, or osteoporosis. Most of the participants in the trial were not deficient and may have already reached the level of vitamin D needed for bone health. Our ongoing studies focus on whether free vitamin D levels or genetic variation in vitamin D absorption, metabolism, or receptor function will provide information about individuals who may benefit from supplemental vitamin D on musculoskeletal health. “

JoAnn Manson, MD, co-author and chair of the Division of Preventive Medicine at Brigham.

Reference: “Supplemental Vitamin D and Accidental Fractures in Middle Age and Older Adults” by Merrill S. MD, Eunjung Kim, MS, Peggy M. Cawthon, Ph.D. , MPH, Douglas C. Bauer, MD, Dennis Black, Ph.D. J. Chris Gallagher, MD, I-Min Lee, MB, BS, Sc.D., Julie E. Buring, Sc.D., and JoAnn E. Manson, MD, Dr.PH, 28 July 2022, New England Journal of Medicine.
doi: 10.1056/NEJMoa2202106

Funding: National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases

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