Scientists recently conducted a series of studies to test the biosafety and neurobehavioral effects of 33.0 Tesla High Static Magnetic Fields (SMF) using the self-designed High Static Magnetic Field Facility (SHMFF) biological research platform. The experiments were carried out by Professor Shen Zhang’s team at the Hefei Institutes of Physical Sciences of the Chinese Academy of Sciences.
They have reported, for the first time, the biosafety of 30 Tesla level SMF and the neurobehavioral effects of 20 Tesla and 30 Tesla level SMF on healthy mice in Magnetic Resonance Imaging Journal And the European rays.
In recent years, ultra-high field magnetic resonance imaging (MRI) has developed rapidly due to its great advantage of high imaging resolution. 7 Tesla MRI has been clinically approved and 21.1 Tesla MRI has been used successfully in rodents. However, studies on the biosafety of high magnetic fields above 20 Tesla are still scarce, and there is still a gap in relevant studies above 30 Tesla.
Based on the previous biosafety study of 3.5-23.0 Tesla SMF, the Xin Zhang group increased the magnetic field strength and shortened the exposure time. Healthy C57BL/6J mice were exposed to 7.0-33.0 Tesla SMF for 1 hour.
After exposure, all mice were routinely fed for 2 months. Except for a few metabolic, hepatocellular and renal indices affected by the magnetic field, the complete blood count and tissue organ parameter of major organs were not seriously affected, and most of the mice remained within the normal reference range.
Meanwhile, behavioral tests showed that elevated SMF alleviated anxiety and improved social and spatial memory in mice within two months after exposure.
In addition to, Behavioral studies of healthy mice exposed to a magnetic field of 3.5–23.0 Tesla for 2 h also found enhanced neurocognitive effects, which may be associated with increased expression of calcium/calodulin-dependent protein kinase 2 in the mouse hippocampus.
Zhang’s group also found that 7 Tesla SMF can effectively relieve the symptoms of depressed mice. These findings not only provide useful safety information for the development of ultra-high SMF, but may also indicate that elevated SMF has the potential to be an antidepressant therapy in the future.
Reference: “Short and Long-Term Effects of Ultra-High Magnetic Fields from 3.5 to 23.0 Tesla on Rat Behavior” by Md Hasanuzzaman Khan, Xinfeng Huang, Xiaofei Tian, Changjie Ouyang, Dongmei Wang, Shuang Feng, Jutao Chen, Tian Xue, Jin Bao and Chen Zhang March 16, 2022, European Radiology.
This study was supported by the National Research and Development Program of the Ministry of Science and Technology, the National Natural Science Foundation of China, the President’s Fund of Hefei Institutes of Physical Sciences, etc.