Scientific experience has proven that diet supplementation can prevent hereditary cancer

Resistant starch has been shown to have a significant protective effect on a wide range of cancers in people with high genetic risk.

Can a banana a day protect against cancer?

A significant protective effect of resistant starch on a wide range of cancers was shown in a trial in people with high genetic risk. Resistant starch can be found in a variety of foods such as oats, breakfast cereals, pasta or cooked and cooled rice, peas, beans, and slightly green bananas.

An international trial revealed that a regular dose of resistant starch, also known as fermented fiber, taken for an average of two years, did not affect cancers in the intestine but reduced cancers in other parts of the body by more than half. This effect was particularly pronounced for upper gastrointestinal cancers including those of the esophagus, stomach, bile ducts, pancreas, and duodenum. The trial – known as CAPP2 – involved nearly 1,000 Lynch syndrome patients from around the world.

Furthermore, the amazing effect was observed to persist for 10 years after stopping the supplement.

The study is a 10-year, double-blind, planned follow-up, supplemented with comprehensive National Cancer Registry data for up to 20 years in 369 participants. The research was led by experts at the Universities of Newcastle and Leeds and was published on 25 July 2022, in Cancer prevention researchwhich is the journal of the American Association for Cancer Research.

Previous research published as part of the same trial revealed that aspirin reduced large bowel cancer by 50%.

“We found that resistant starch reduced a range of cancers by more than 60%. The effect was most pronounced in the upper gut,” explained Professor John Mathers, Professor of Human Nutrition at Newcastle University. “This is important because upper gastrointestinal cancers are difficult to diagnose and often It is not detected early.

“Resistant starch can be taken as a powder supplement and is found naturally in peas, beans, oats and other starchy foods. The dose used in the experiment is equivalent to eating a banana a day. Before the bananas are too ripe and soft, the starch in the bananas resists decomposition and reaches the intestines where it can alter the type of bacteria that you live there.

“Resistant starch is a type of carbohydrate that is not digested in the small intestine, but ferments in the large intestine, feeding beneficial gut bacteria—in fact, it acts like dietary fiber in the digestive system. This type of starch has many health benefits and fewer calories than Regular starch We think resistant starch may reduce the development of cancer by altering the bacterial metabolism of bile acids and reducing those types of bile acids that can harm us.[{” attribute=””>DNA and eventually cause cancer. However, this needs further research.”

Professor Sir John Burn, from Newcastle University and Newcastle Hospitals NHS Foundation Trust who ran the trial with Professor Mathers, said: “When we started the studies over 20 years ago, we thought that people with a genetic predisposition to colon cancer could help us to test whether we could reduce the risk of cancer with either aspirin or resistant starch.

“Patients with Lynch syndrome are high risk as they are more likely to develop cancers so finding that aspirin can reduce the risk of large bowel cancers and resistant starch other cancers by half is vitally important.

“Based on our trial, NICE now recommends Aspirin for people at high genetic risk of cancer, the benefits are clear – aspirin and resistant starch work.”

Long term study

Nearly 1000 participants between 1999 and 2005 began either taking resistant starch in a powder form every day for two years or aspirin or a placebo.

At the end of the treatment stage, there was no overall difference between those who had taken resistant starch or aspirin and those who had not. However, the research team anticipated a longer-term effect and designed the study for further follow-up.

There were just 5 new cases of upper GI cancers among the 463 participants who had taken the resistant starch compared with 21 among the 455 who were on the placebo in the period of follow-up.

The team is now leading the international trial, CaPP3, with more than 1,800 people with Lynch syndrome enrolled to look at whether smaller, safer doses of aspirin can be used to help reduce the cancer risk.

Reference: “Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up” by John C. Mathers, Faye Elliott, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Möslein Fiona E. McRonald, Lucio Bertario, D. Gareth Evans, Anne-Marie Gerdes, Judy W.C. Ho, Annika Lindblom, Patrick J. Morrison, Jem Rashbass, Raj S. Ramesar, Toni T. Seppälä, Huw J.W. Thomas, Harsh J. Sheth, Kirsi Pylvänäinen, Lynn Reed, Gillian M. Borthwick, D. Timothy Bishop and John Burn on behalf of the CAPP2 Investigators, 25 July 2022, Cancer Prevention Research.
DOI: 10.1158/1940-6207.CAPR-22-0044

The research is funded by Cancer Research UK, the European Commission, Medical Research Council, and the National Institute for Health Research.

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