Mayo Clinic: DNA may determine severity of each individual COVID-19 case

Mayo Clinic researchers say they may have found a genetic explanation for why COVID-19 is severe in some people and mild in others.

If research continues, knowing how the SARS-CoV-2 virus behaves will be a stark contrast to the beginning of the pandemic, when all potentially vulnerable groups took extra precaution for fear of infection.

According to the Mayo Clinic, Rochester scientists have discovered mutations in two human proteins that may determine an individual’s susceptibility to COVID-19 symptoms.

The researchers examined DNA sequencing data from around the world to look for differences that could affect “disease outcomes”. The findings relate to the main idea that proteins play many critical roles in the function of the human body.

“To our knowledge, this is the first time anyone has applied this approach to COVID-19,” said study co-author Dr Richard Winshelbaum.

Many people may be unsure of what human proteins are and what they do in the human body.

National Institutes of Health (NIH) information says that proteins, which are large, complex molecules in our bodies, do most of the work in our cells and are essential for the function of body tissues and organs.

Our DNA contains the instructions for making those proteins. Therefore, genetic differences from person to person affect the proteins.

In order to demonstrate the importance of protein expression to disease in general, the National Institutes of Health’s National Cancer Institute says that protein expression in cancer cells may be related to certain types of cancers and the effectiveness of certain treatments. The Institute of Cancer defines protein expression as “the production of proteins by cells.”

While the COVID-19 virus and cancer are very different, the release of the Mayo Clinic study highlights one of the ways scientists are trying to discover how COVID-19 has led to millions of deaths worldwide while other infected people never have a single symptom.

Variations in genes Ice 2 And the Tempris 2 It can lead to an increase or decrease in protein expression. Increased protein expression may lead to a higher susceptibility and severity to COVID-19 virus, while a decrease may have a protective effect against the virus…in this caseACE2 And the Tempris 2 Providing critical entry points for SARS-CoV-2 to invade and infect human cells,” the Mayo Clinic release explained.

The study was conducted by the Mayo Clinic team in Rochester, led by Lingxin Zhang of the Mayo Clinic Department of Clinical Pharmacology.

PDF version of Ice 2 And the Tempres 2 SARS-CoV-2 infection genes: deep mutational scanning and characterization of missense variants”, published in human molecular geneticscan be found here.

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