Pestal, K et al. Isoforms of the RNA-editing enzyme ADAR1 independently control the DNA sensor in autoimmunity and MDA5-led multiorgan development. immunity 43933-944 (2015).
Ahmed, S. et al. The breach of self-tolerance with Alu duplex RNA underlies MDA5-mediated inflammation. cell 172797-810 (2018).
Herbert, A. et al. The Z-DNA binding domain is present in the human editing enzyme, RNA double-stranded adenosine deaminase. Brooke. Acad Natel. Sciences. United States of America 948421-8426 (1997).
Rice, GI et al. mutations in ADAR1 Aicardi-Gautier syndrome associated with a type 1 antiviral signature. nat. Genet. 441243-1248 (2012).
Murano, M et al. Protein kinase R and the integrated stress response drive the immunopathology caused by mutations in the RNA deaminase ADAR1. immunity 541948-1960 (2021).
Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U. & Rich, A. The structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-associated proteins. nat. structure. mall. Biol. 8761-765 (2001).
Ripsamine, M et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homologous interaction forms to activate NF-κB. EMBO representative. 10916-922 (2009).
Thapa, RJ et al. DAI senses the genomic RNA of influenza A virus and activates RIPK3-dependent cell death. host cell microbe 20674-681 (2016).
Upton, J.W., Kaiser, W.G. and Mukarsky, ES DAI/ZBP1/DLM-1 complexes with RIP3 mediate virus-induced programmed necrosis targeted by cytomegalovirus vera. host cell microbe 11290-297 (2012).
Chung, H et al. Human ADAR1 prevents endogenous RNA from triggering translational arrest. cell 172811-824 (2018).
Lee, Wai et al. Ribonuclease L mediates the lethal cell-deprived phenotype of ADAR1-editing double-stranded RNA in a human cell line. Elevi 6e25687 (2017).
Crowe, YJ et al. Characterization of human disease phenotypes associated with mutations in TREX1And the RNASEH2AAnd the RNASEH2BAnd the RNASEH2CAnd the SAMHD1And the ADARAnd the IFIH1. I be. J. Mead. Genet. a 167296-312 (2015).
Ishi, KJ et al. TANK-associated kinase-1 determines the innate and adaptive immune responses to DNA vaccines. temper nature 451725-729 (2008).
Koehler, H.S., Feng, Y., Mandal, P. & Mocarski, E.S. Identification of the limits of function of the Z-DNA-binding protein (ZBP1/DAI/DLM1). FEBS J. 2874362-4369 (2020).
Newton, K et al. RIPK1 suppresses ZBP1-induced necroptosis during development. temper nature 540129-133 (2016).
Takaoka, A. et al. DAI (DLM-1/ZBP1) is a cellular DNA sensor and an activator of the innate immune response. temper nature 448501-505 (2007).
Nogusa, S. et al. RIPK3 activates parallel pathways of MLKL-driven necrosis and FADD-mediated apoptosis to protect against influenza A virus. host cell microbe 2013-24 (2016).
Varfolomeev, E. E. et al. Targeted disruption of the mouse caspase-8 gene eliminates the induction of cell death by TNF receptors, Fas/Apo1, and DR3 and is a prenatal lethal. immunity 9267-276 (1998).
Oberst, A. et al. The catalytic activity of caspase-8-FLIPThe It prevents RIPK3-dependent necrosis. temper nature 471363–367 (2011).
Kaiser, WJ et al. RIP3 mediates embryonic death of caspase-8-deficient mice. temper nature 471368-372 (2011).
Alvarez Diaz, S et al. The MLKL pseudokinase and the kinase RIPK3 both play distinct roles in autoimmune diseases caused by loss of death receptor-induced apoptosis. immunity 45513-526 (2016).
Al-Najjar, M et al. The kinases RIPK1 and RIPK3 promote cell death-independent inflammation by Toll-like receptor 4. immunity 4546-59 (2016).
Rothenburg, S et al. The eukaryotic initiation factor similar to PKR 2α kinase from zebrafish contains Z-DNA-binding domains rather than dsRNA-binding domains. Brooke. Acad Natel. Sciences. United States of America 1021602-1607 (2005).
Koehler, H et al. Vaccine virus E3 inhibits Z-RNA sensing to prevent ZBP1-dependent necroptosis. host cell microbe 291266-1276 (2021).
Gray, EE, Treuting, PM, Woodward, JJ & Stetson, DB Latest technology: cGAS is required for a lethal autoimmune disease in a Trex1-deficient mouse model of Aicardi-Goutières syndrome. J. Immunol. 1951939–1943 (2015).
Gal et al. Autoimmunity begins in non-hematopoietic cells and develops through lymphocytes in an interferon-dependent autoimmune disease. immunity 36120-131 (2012).
Murphy, JM et al. Pseudokinase MLKL mediates necroptosis via a molecular switching mechanism. immunity 39443-453 (2013).
Kasparkova, F.; et al. Recent Developments: RIP1 kinase activity is dispensable for normal development but is a major regulator of inflammation in Sharpin-deficient mice. Immunol. 1925476–5480 (2014).
Lin, J. et al. RIPK1 interferes with ZBP1-mediated necroptosis to inhibit inflammation. temper nature 540124–128 (2016).
Newton, K., Sun, X. & Dixit, and VM Kinase RIP3 are dispensable for normal NF-kappa Bs, signaling B-cell receptors, T cells, tumor necrosis factor receptors 1, and Sketch-like receptors 2 and 4. mall. cell. Biol. 241464-1469 (2004).
Salmena, L. et al. An essential role for caspase 8 in T-cell homeostasis and T-cell immunity. Jane Dave. 17883-895 (2003).
Henao-Mejia, J. et al. Generation of transgenic mice using the CRISPR-Cas9 genome editing system. Cold Spring War. Protok. https://doi.org/10.1101/pdb.prot090704 (2016).
Shen, K.-J. et al. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated gene expression. Brooke. Acad Natel. Sciences. United States of America 10313759–13764 (2006).
Zarnegar, B.J. et al. The irCLIP platform for efficient characterization of protein and RNA interactions. nat. Methods 13489-492 (2016).
Orozco, S et al. RIPK1 positively and negatively regulates both RIPK3 oligomerization and necroptosis. Cell death varies. 211511-1521 (2014).
Bray, N.L., Pimentel, H., Melsted, P. & Pachter, L. Semi-optimal probabilistic quantification of RNA-seq. nat. Biotechnology. 34525-527 (2016).
Ewels, P., Magnusson, M., Lundin, S. & Käller, M. MultiQC: Summarizing analysis results for multiple instruments and samples in a single report. bioinformatics 323047-3048 (2016).
Love, MI, Huber, W. & Anders, S. Moderate estimation of fold change and dispersion for RNA-seq data using DESeq2. Genome Biol. 15th550 (2014).
Durinck, S. et al. BioMart and Bioconductor: A powerful link between biological databases and microarray data analysis. bioinformatics 213439–3440 (2005).
Durinck, S., Spellman, P.T., Birney, E. & Huber, W. Mapping identifiers for integrating genomic data sets with the R/Bioconductor biomaRt package. nat. Protok. 41184–1191 (2009).
Yu, G., Wang, L.-G. Han, Y. & He, Q.-Y. clustProfiler: An R package for comparing biological subjects between gene sets. OMICS J. Integr. Biol. 16284-287 (2012).