ADAR1 mutation causes ZBP1-dependent immunopathology

  • Pestal, K et al. Isoforms of the RNA-editing enzyme ADAR1 independently control the DNA sensor in autoimmunity and MDA5-led multiorgan development. immunity 43933-944 (2015).

    Article CAS Scholar from Google

  • Ahmed, S. et al. The breach of self-tolerance with Alu duplex RNA underlies MDA5-mediated inflammation. cell 172797-810 (2018).

    Article CAS Scholar from Google

  • Herbert, A. et al. The Z-DNA binding domain is present in the human editing enzyme, RNA double-stranded adenosine deaminase. Brooke. Acad Natel. Sciences. United States of America 948421-8426 (1997).

    ADS CAS Article Google Scholar

  • Rice, GI et al. mutations in ADAR1 Aicardi-Gautier syndrome associated with a type 1 antiviral signature. nat. Genet. 441243-1248 (2012).

    Article CAS Scholar from Google

  • Murano, M et al. Protein kinase R and the integrated stress response drive the immunopathology caused by mutations in the RNA deaminase ADAR1. immunity 541948-1960 (2021).

    Article CAS Scholar from Google

  • Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U. & Rich, A. The structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-associated proteins. nat. structure. mall. Biol. 8761-765 (2001).

    Article CAS Scholar from Google

  • Ripsamine, M et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homologous interaction forms to activate NF-κB. EMBO representative. 10916-922 (2009).

    Article CAS Scholar from Google

  • Thapa, RJ et al. DAI senses the genomic RNA of influenza A virus and activates RIPK3-dependent cell death. host cell microbe 20674-681 (2016).

    Article CAS Scholar from Google

  • Upton, J.W., Kaiser, W.G. and Mukarsky, ES DAI/ZBP1/DLM-1 complexes with RIP3 mediate virus-induced programmed necrosis targeted by cytomegalovirus vera. host cell microbe 11290-297 (2012).

    Article CAS Scholar from Google

  • Chung, H et al. Human ADAR1 prevents endogenous RNA from triggering translational arrest. cell 172811-824 (2018).

    Article CAS Scholar from Google

  • Lee, Wai et al. Ribonuclease L mediates the lethal cell-deprived phenotype of ADAR1-editing double-stranded RNA in a human cell line. Elevi 6e25687 (2017).

    Google Scholar article

  • Crowe, YJ et al. Characterization of human disease phenotypes associated with mutations in TREX1And the RNASEH2AAnd the RNASEH2BAnd the RNASEH2CAnd the SAMHD1And the ADARAnd the IFIH1. I be. J. Mead. Genet. a 167296-312 (2015).

    Article CAS Scholar from Google

  • Ishi, KJ et al. TANK-associated kinase-1 determines the innate and adaptive immune responses to DNA vaccines. temper nature 451725-729 (2008).

    ADS CAS Article Google Scholar

  • Koehler, H.S., Feng, Y., Mandal, P. & Mocarski, E.S. Identification of the limits of function of the Z-DNA-binding protein (ZBP1/DAI/DLM1). FEBS J. 2874362-4369 (2020).

    Article CAS Scholar from Google

  • Newton, K et al. RIPK1 suppresses ZBP1-induced necroptosis during development. temper nature 540129-133 (2016).

    ADS CAS Article Google Scholar

  • Takaoka, A. et al. DAI (DLM-1/ZBP1) is a cellular DNA sensor and an activator of the innate immune response. temper nature 448501-505 (2007).

    ADS CAS Article Google Scholar

  • Nogusa, S. et al. RIPK3 activates parallel pathways of MLKL-driven necrosis and FADD-mediated apoptosis to protect against influenza A virus. host cell microbe 2013-24 (2016).

    Article CAS Scholar from Google

  • Varfolomeev, E. E. et al. Targeted disruption of the mouse caspase-8 gene eliminates the induction of cell death by TNF receptors, Fas/Apo1, and DR3 and is a prenatal lethal. immunity 9267-276 (1998).

    Article CAS Scholar from Google

  • Oberst, A. et al. The catalytic activity of caspase-8-FLIPThe It prevents RIPK3-dependent necrosis. temper nature 471363–367 (2011).

    ADS CAS Article Google Scholar

  • Kaiser, WJ et al. RIP3 mediates embryonic death of caspase-8-deficient mice. temper nature 471368-372 (2011).

    ADS CAS Article Google Scholar

  • Alvarez Diaz, S et al. The MLKL pseudokinase and the kinase RIPK3 both play distinct roles in autoimmune diseases caused by loss of death receptor-induced apoptosis. immunity 45513-526 (2016).

    Article CAS Scholar from Google

  • Al-Najjar, M et al. The kinases RIPK1 and RIPK3 promote cell death-independent inflammation by Toll-like receptor 4. immunity 4546-59 (2016).

    Article CAS Scholar from Google

  • Rothenburg, S et al. The eukaryotic initiation factor similar to PKR 2α kinase from zebrafish contains Z-DNA-binding domains rather than dsRNA-binding domains. Brooke. Acad Natel. Sciences. United States of America 1021602-1607 (2005).

    ADS CAS Article Google Scholar

  • Koehler, H et al. Vaccine virus E3 inhibits Z-RNA sensing to prevent ZBP1-dependent necroptosis. host cell microbe 291266-1276 (2021).

    Article CAS Scholar from Google

  • Gray, EE, Treuting, PM, Woodward, JJ & Stetson, DB Latest technology: cGAS is required for a lethal autoimmune disease in a Trex1-deficient mouse model of Aicardi-Goutières syndrome. J. Immunol. 1951939–1943 (2015).

    Article CAS Scholar from Google

  • Gal et al. Autoimmunity begins in non-hematopoietic cells and develops through lymphocytes in an interferon-dependent autoimmune disease. immunity 36120-131 (2012).

    Article CAS Scholar from Google

  • Murphy, JM et al. Pseudokinase MLKL mediates necroptosis via a molecular switching mechanism. immunity 39443-453 (2013).

    Article CAS Scholar from Google

  • Kasparkova, F.; et al. Recent Developments: RIP1 kinase activity is dispensable for normal development but is a major regulator of inflammation in Sharpin-deficient mice. Immunol. 1925476–5480 (2014).

    Google Scholar

  • Lin, J. et al. RIPK1 interferes with ZBP1-mediated necroptosis to inhibit inflammation. temper nature 540124–128 (2016).

    ADS CAS Article Google Scholar

  • Newton, K., Sun, X. & Dixit, and VM Kinase RIP3 are dispensable for normal NF-kappa Bs, signaling B-cell receptors, T cells, tumor necrosis factor receptors 1, and Sketch-like receptors 2 and 4. mall. cell. Biol. 241464-1469 (2004).

    Article CAS Scholar from Google

  • Salmena, L. et al. An essential role for caspase 8 in T-cell homeostasis and T-cell immunity. Jane Dave. 17883-895 (2003).

    Article CAS Scholar from Google

  • Henao-Mejia, J. et al. Generation of transgenic mice using the CRISPR-Cas9 genome editing system. Cold Spring War. Protok. https://doi.org/10.1101/pdb.prot090704 (2016).

  • Shen, K.-J. et al. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated gene expression. Brooke. Acad Natel. Sciences. United States of America 10313759–13764 (2006).

    ADS CAS Article Google Scholar

  • Zarnegar, B.J. et al. The irCLIP platform for efficient characterization of protein and RNA interactions. nat. Methods 13489-492 (2016).

    Article CAS Scholar from Google

  • Orozco, S et al. RIPK1 positively and negatively regulates both RIPK3 oligomerization and necroptosis. Cell death varies. 211511-1521 (2014).

    Article CAS Scholar from Google

  • Bray, N.L., Pimentel, H., Melsted, P. & Pachter, L. Semi-optimal probabilistic quantification of RNA-seq. nat. Biotechnology. 34525-527 (2016).

    Article CAS Scholar from Google

  • Ewels, P., Magnusson, M., Lundin, S. & Käller, M. MultiQC: Summarizing analysis results for multiple instruments and samples in a single report. bioinformatics 323047-3048 (2016).

    Article CAS Scholar from Google

  • Love, MI, Huber, W. & Anders, S. Moderate estimation of fold change and dispersion for RNA-seq data using DESeq2. Genome Biol. 15th550 (2014).

    Google Scholar article

  • Durinck, S. et al. BioMart and Bioconductor: A powerful link between biological databases and microarray data analysis. bioinformatics 213439–3440 (2005).

    Article CAS Scholar from Google

  • Durinck, S., Spellman, P.T., Birney, E. & Huber, W. Mapping identifiers for integrating genomic data sets with the R/Bioconductor biomaRt package. nat. Protok. 41184–1191 (2009).

    Article CAS Scholar from Google

  • Yu, G., Wang, L.-G. Han, Y. & He, Q.-Y. clustProfiler: An R package for comparing biological subjects between gene sets. OMICS J. Integr. Biol. 16284-287 (2012).

    Article CAS Scholar from Google

  • Leave a Reply

    %d bloggers like this: